The Business Environment of 1995 as Seen by Wisconsin Business Executives

Like many states, particularly those in the so-called rust bucket of the industrial north, Wisconsin is concerned about its business climate. A number of different steps with the potential to make Wisconsin\u27s business environment more hospitable have been taken. For example, the state income tax has been reduced; the state has partially funded a business development organization, Forward Wisconsin, to attract new companies to the area; and a state-appointed panel, the Wisconsin Strategic Development Commission, has filed its recommendations concerning the actions that should be considered in revitalizing the region\u27s business community. This article provides another perspective. It reports upon the views held by a sample of Wisconsin business executives concerning the nature of the business environment in 1995. Specifically, this paper reports on the perceptions held by 24 executives (mostly vice presidents of planning or marketing) from Wisconsin corporations. Because vice-presidents of planning and marketing are most responsible for translating environmental trends into strategic actions, we believe their vision of the general business climate in 1995 will be of keen interest to those concerned about the future of Wisconsin\u27s economy

Intergrating ERP Across the Curriculum: A Phased, Three-Tiered Approach

The authors propose a phased, three-tiered approach for incorporating enterprise system software into the curriculum. The courses in each tier have different objectives and requirements. By phasing in the tiers over time, maximum student exposure and minimal course disruption is achieved. The authors illustrate this approach by discussing the on-going implementation of SAP R/3 into the curriculum at one university

Determinants of Graduating MIS Students Starting Salary in Boom and Bust Job Markets

This study investigates the influence of internship experience, grade-point average (GPA), and job market on the starting salaries of management information systems (MIS) graduates. The seven-year period of the study includes the strong job market of the Internet boom, as well as the weak job market following the Internet bust. The regression results indicate that several factors are significantly related to starting salary including internship experience, GPA, job market, and size of employer. Internship experience was found to play a particularly strong role in predicting MIS starting salaries. A significant interaction effect indicates that the positive effect of internship experience is stronger during a weak job market. Graduates with internship experience also found employment more quickly. The study is based upon academic and placement data collected from 126 graduates from an AACSB accredited MIS program at Western Washington University during the years 1997-2003

The social TV phenomenon and fake online restaurant reviews

Purpose – The social TV phenomenon has raised the interest of some researchers in studying the production of online reviews. However, little is known about the characteristics of reviewers that, without having had indeed a real experience of consumption, still dare to assess the service. The purpose of this research is to understand these reviewers better, using an experiment conducted in Brazil. Design/methodology/approach – Through a cluster analysis with 2547 reviewers of 7 restaurants that participated in a reality show in Brazil, we were able to create 4 fours. Using Spearman Correlation and Kruskal-Wallis Test, differences among groups were analysed in the search of behavioural changes among different types of reviewers. Findings – We conclude that social TV influence fake online reviews of restaurants that were involved in a tv show. Furthermore, we were able to verify that some reviewers indeed assess the service without indeed having tried the service, which strongly bias the influence they are going to cause in potential consumers. Four types of reviewers were identified: the real expert, the amateur reviewer, the speculator and the pseudo expert. The 2 latter types are analyzed through the anthropologic lens of the popular Brazilian culture and the TV influence in that country. Research limitations/implications – we were able to understand how TV can influence the construction of fake online reviews for restaurants. Practical implications – It is important for the restaurant and hospitality industry in general, to be able to be attentive to the phenomenon of fake reviews that can totally biased the advantages of this assessment system that was created to produce trust among consumers, but that can act exactly the other way around. Originality/value – This study highlights the relevance of taking into account cultural background of the country where the restaurant is located, as well as emphasizing the relevance of conducting a previous analysis of the decision of embarking on a reality show that it has high chances to biasedly influence consumers’ decisions.info:eu-repo/semantics/publishedVersio

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural product whose molecular mode of action was unknown. The new ternatin variants are cytotoxic toward cancer cells, with up to 500-fold greater potency than ternatin itself. Using a ternatin photo-affinity probe, we identify the translation elongation factor-1A ternary complex (eEF1A·GTP·aminoacyl-tRNA) as a specific target and demonstrate competitive binding by the unrelated natural products, didemnin and cytotrienin. Mutations in domain III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating the adjacent hydrophobic surface as a functional hot spot for eEF1A modulation. We conclude that the eukaryotic elongation factor-1A and its ternary complex with GTP and aminoacyl-tRNA are common targets for the evolution of cytotoxic natural products

2011 Ground Testing Highlights Article

Two tests supporting development of the launch abort system for the Orion MultiPurpose Crew Vehicle were run in the NASA Ames Unitary Plan wind tunnel last year. The first test used a fully metric model to examine the stability and controllability of the Launch Abort Vehicle during potential abort scenarios for Mach numbers ranging from 0.3 to 2.5. The aerodynamic effects of the Abort Motor and Attitude Control Motor plumes were simulated using high-pressure air flowing through independent paths. The aerodynamic effects of the proximity to the launch vehicle during the early moments of an abort were simulated with a remotely actuated Service Module that allowed the position relative to the Crew Module to be varied appropriately. The second test simulated the acoustic environment around the Launch Abort Vehicle caused by the plumes from the 400,000-pound thrust, solid-fueled Abort Motor. To obtain the proper acoustic characteristics of the hot rocket plumes for the flight vehicle, heated Helium was used. A custom Helium supply system was developed for the test consisting of 2 jumbo high-pressure Helium trailers, a twelve-tube accumulator, and a 13MW gas-fired heater borrowed from the Propulsion Simulation Laboratory at NASA Glenn Research Center. The test provided fluctuating surface pressure measurements at over 200 points on the vehicle surface that have now been used to define the ground-testing requirements for the Orion Launch Abort Vehicle

Torque, power and muscle activation of eccentric and concentric isokinetic cycling

This study aimed to establish the effect of cycling mode and cadence on torque, external power output, and lower limb muscle activation during maximal, recumbent, isokinetic cycling. After familiarisation, twelve healthy males completed 6 × 10 s of maximal eccentric (ECC) and concentric (CON) cycling at 20, 40, 60, 80, 100, and 120 rpm with five minutes recovery. Vastus lateralis, medial gastrocnemius, rectus femoris, and biceps femoris surface electromyography was recorded throughout. As cadence increased, peak torque linearly decreased during ECC (350-248 N·m) and CON (239-117 N·m) and peak power increased in a parabolic manner. Crank angle at peak torque increased with cadence in CON (+13°) and decreased in ECC (-9.0°). At all cadences, peak torque (mean +129 N·m, range 111-143 N·m), and power (mean +871 W, range 181-1406 W), were greater during ECC compared to CON. For all recorded muscles the crank angle at peak muscle activation was greater during ECC compared to CON. This difference increased with cadence in all muscles except the vastus lateralis. Additionally, peak vastus laterallis and biceps femoris activation was greater during CON compared to ECC. Eccentric cycling offers a greater mechanical stimulus compared to concentric cycling but the effect of cadence is similar between modalities. Markers of technique (muscle activation, crank angle at peak activation and torque) were different between eccentric and concentric cycling and respond differently to changes in cadence. Such data should be considered when comparing between, and selecting cadences for, recumbent, isokinetic, eccentric and concentric cycling

Formal synthesis of (+)-lactacystin from l-serine

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues